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The applications of FO-PPR (Fiber Optic-Particle Plasmon Resonance) technologies within the field of diagnosis by fishing out proteomics or genomics of interest with optical sensor had been published in over past few years.FO-PPR, a technique by using a narrow wavelength light source through a fiber to excite gold nanoparticles PPR phenomenon, and monitoring the intensity with subsequent photo diode.Molecular binding of an analyte on a bioreceptor-conjugated AuNP is transduced to a change of the light intensity. A biosensor merchandise combined FO-PPR and bioreceptor-conjugated AuNP has been optimized.​​​​​​​