Scientific Publications FOPPR™ Technology Applications:“Apolipoprotein E genetic analysis in unamplified genomic DNA extracts by ligase reaction and fiber optic particle plasmon resonance biosensor.” Sensors and Actuators B 2023, 393, 134237.“Trace determination of grouper nervous necrosis virus in contaminated larvae and pond water samples using label-free fiber optic nanoplasmonic biosensor.” Biosensors 2022, 12, 907.“Ultrasensitive and rapid detection of N-terminal pro-B-type natriuretic peptide (NT- proBNP) using fiber optic nanogold-linked immunosorbent assay.” Biosensors 2022, 12, 746.“Quantitative and amplification-free detection of SOCS-1 CpG methylation percentage analyses in gastric cancer by fiber optic nanoplasmonic biosensor.” Biosensors and Bioelectronics 2022, 214, 114540."The applications of plasmonics biosensor and bamboo char filtration to the prevention of nervous necrosis virus infection in grouper farming ponds." IOP Conf. Ser.: Earth Environ. Sci. 2021, 686, 012003.“Detection of Hg(II) at part-per-quadrillion levels by fiber optic plasmonic absorption using DNA hairpin and DNA-gold nanoparticle conjugates.” ACS Applied Nano Materials 2021, 4, 10128-10135.“MutS protein-based fiber optic particle plasmon resonance biosensor for detecting single nucleotide polymorphisms.” Analytical and Bioanalytical Chemistry 2021, 413, 3329-3337."A fiber optic nanoplasmonic biosensor for the sensitive detection of ampicillin and its analogs." Microchimica Acta 2020, 187, 396."Fiber optic particle plasmon resonance biosensor for label-free detection of nucleic acids and its application to HLA-B27 mRNA detection in patients with ankylosing spondylitis." Sensors 2020, 20, 3137."Fiber optic particle plasmon resonance immunosensor for rapid and sensitive detection of methamphetamine based on competitive inhibition." Microchemical Journal 2020, 157, 105026."Fiber optic nanogold-linked immunosorbent assay for rapid detection of procalcitonin at femtomolar concentration level." Biosensors and Bioelectronics 2020, 151, 111871."Anti‐MDA5 detection in patients with inflammatory myositis." International Journal of Rheumatic Diseases, 20th Asia Pacific League of Associations for Rheumatology Congress (APLAR 2018). Kaohsiung, Taiwan."Binding Kinetic Constants Measurement by Using Fiber Optic Particle Plasmon Resonance Biosensor." Lab-on-a-Chip & Microfluidics, Point-of-Care Diagnostics & Global Health Asia 2017. Taipei, Taiwan."Direct detection of orchid viruses using nanorod-based fiber optical particle plasmon resonance immunosensor." Biosensors and Bioelectronics 2014, 51, 371-378."Quantification of tumor necrosis factor-a and matrix metalloproteinases-3 in synovial fluid by a fiber-optic particle plasmon resonance sensor." Analyst 2013, 138, 4599-4606."Using a fiber optic particle plasmon resonance biosensor to determine kinetic constants of antigen-antibody binding reaction." Analytical Chemistry 2013, 85, 245-250."Fiber-optic particle plasmon resonance sensor for detection of interleukin-1b in synovial fluids." Biosensors and Bioelectronics 2010, 26, 1036-1042."Detection of antinuclear antibodies by a colloidal gold modified optical fiber: comparison with ELISA." Analytical and Bioanalytical Chemistry 2007, 388, 901-907.Scientific Publications Nanoplasmonic Optical Fiber Sensing Platform/Biochips:“Integration of power-free and self-contained microfluidic chip with fiber optic particle plasmon resonance aptasensor for rapid detection of SARS-CoV-2 nucleocapsid protein.” Biosensors 2022, 12, 785."Integrated graphene oxide with noble metal nanoparticles to develop high-sensitivity fiber optic particle plasmon resonance (FOPPR) biosensor for biomolecules determination." Nanomaterials 2021, 11(3), 635.“Dual-functional gold-iron oxide core-satellite hybrid nanoparticles for sensitivity enhancement in biosensors via nanoplasmonic and preconcentration effects.” Analyst 2021, 146, 6935-6943."Fiber optic particle plasmon resonance-based immunoassay using a novel multi-microchannel Biochip." Sensors 2020, 20(11), 3086."Self-referencing fiber optic particle plasmon resonance sensing system for real-time biological monitoring." Talanta 2016, 146, 291-298."Multiple resonance fiber-optic sensor with time division multiplexing for multi-analyte detection." Optics Letters 2012, 37, 3969-3971."Improved performance of aminopropylsilatrane over aminopropyltriethoxysilane as a linker for nanoparticle-based plasmon resonance sensors." Sensors and Actuators B 2012, 163, 207-215."Fiber optic particle plasmon resonance sensor based on plasmonic light scattering interrogation." Annalen der Physik 2012, 524, 705-712."A fiber optic particle plasmon resonance biosensing platform based on detection of light scattering intensity from the proximal end." Journal of The Chinese Chemical Society 2011, 58, 786-792."Integration of fiber optic-particle plasmon resonance biosensor with microfluidic chip." Analytica Chimica Acta 2011, 697, 75-82.“Using ac field induced electro-osmosis to accelerate biomolecular binding in fiber optic sensing chips with micro-structures.” Analytical Chemistry 2010, 82, 1123- 1127."Novel U-shape gold nanoparticles-modified optical fiber for localized plasmon resonance sensing." Microsystem Technologies 2010, 16, 1207-1214."Novel D-type Fiber Optic Localized Plasmon Resonance Sensor Realized by Femtosecond Laser Engraving." Journal of Laser Micro/NanoEngineering 2010, 5, 1-5."A novel design of grooved fibers for fiber-optic localized plasmon resonance biosensors." Sensors 2009, 9, 6456-6470."Sensing capability of the localized surface plasmon resonance of gold nanorods." Biosensors and Bioelectronics 2007, 22, 926-932."Fiber-optic chemical and biochemical probes based on localized surface plasmon resonance." Sensors and Actuators B 2006, 113, 100-105.“Fiber optic biochemical sensing with a colloidal gold-modified long period fiber grating.” Sensors and Actuators B 2006, 119, 105-109."Sol-gel-coated poly (methyl methacrylate) as a substrate for localized surface plasmon resonance biosensors." Journal of Biomedical Nanotechnology 2005, 1, 143-150."Colloidal gold modified optical fiber for chemical and biochemical Sensing." Analytical Chemistry 2003, 75, 16-21.
Application Notes - FOPPR™ Technology:Epitope Binning: A Critical Step in Antibody Development via Direct AssayAntinuclear Antibody Detection for Autoimmune Diseases via Direct Detection AssayIL-1β (beta) Detection in Osteoarthritis via Direct Detection AssayTNF-α (alpha) Detection for Osteoarthritis via Direct Detection AssayProcalcitonin Detection for Sepsis via Enhancement AssayTechnical Notes FOPPR™ Technology:From Analysis of Antibodies Selection to Ultra Sensitivity Biomarker Detection – Case Study: Neurofilament light (NFL)Why the Light-Sensing Biomarker Analyzer? – System Sensitivity, Compactibility, and ReliabilityStandard and Sensor Chip Wet Storage – A General Guide for NanoAu-MM Standard and Sensor Chips Determining the Kinetic & Affinity Constants of an Analyte – A Practical Guide to the FOPPR™ Binding Kinetics Software Sensor Chip Reuse – Surface RegenerationStandard and Sensor Chip NanoAu-MM Customization – Receptor Ligand Immobilization via Amine Coupling
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