The unique & patented FOPPR™ Technology is combining optical waveguides with noble metal nanoparticles for the sensitive and reliable detection of molecules. In FOPPR™, gold nanoparticles (AuNPs) are in close proximity to an unclad optical fiber. As light propagates within the optical fiber, total internal reflection (TIR) results in an evanescent field that induces the AuNPs to undergo particle plasmon resonance (PPR).
As a derivation of surface plasmon resonance (SPR), PPR of noble metal nanoparticles is the collective oscillation of conductive electrons at the nanoparticle surface in response to incident light of a particular wavelength. The extreme sensitivity of this optical property to changes in the surrounding environment makes FOPPR™ an ideal technology for monitoring real-time interactions between a wide range of molecular species, including but not limited to organic drugs, oligonucleotides, proteins, and viruses.
Molecular detection is achieved through the capture of free-flowing analytes by bioreceptors chemically bound to the FOPPR™ sensing surface. As target analytes are introduced to the sensing surface by the sample fluid, binding interactions between analytes and bioreceptors lead to a change of refractive index near the sensing surface. This refractive index change local to the sensing surface results in an immediate change in optical response proportional to the mass concentration of bound analytes. The label-free and biointeraction-based detection of FOPPR™ enables a wide range of applications in biochemical research, development and diagnostic processes.
光纖式電漿共振技術(FOPPR™)
獨特並獲得專利的FOPPR™技術結合光學波與貴金屬奈米粒子，用於對分子進行高靈敏的可靠偵測。在FOPPR™中，金奈米粒子(AuNPs)與未包覆的光纖緊密相連，當光在光纖內傳播時，全內反射(TIR)會產生一個誘導AuNPs發生粒子質子共振(PPR)的誘導場。
作為表面質子共振(SPR)的衍生物，貴金屬奈米粒子的PPR，是指奈米粒子表面的導電電子對特定波長入射光的集體共振。這種光學特性對周圍環境的變化極度敏感，使得FOPPR™成為監測多種分子種類實時相互作用的理想技術，包括有機藥物、寡核苷酸、蛋白質和病毒等不同應用。
分子檢測是透過與FOPPR™感測表面化學結合的生物接受器，結合自由流動的分析物，來得以實現。當目標分析物隨著樣品液引入感測表面時，分析物和生物接受器之間的結合相互作用，導致感測表面附近的折射率產生變化。這種感測表面局部的折射率變化，即會導致光學響應產生立即變化，其變化與被分析物的質量濃度成正比。FOPPR™技術具有無標記定量分析之特性，所以可廣泛的應用於研究生物相互作用的檢測，並在生化研究、開發和診斷過程佔有重要的一席之地。
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